Protein Engineering Companies

EvolutionaryScale

New York, United States

EvolutionaryScale develops generative AI models for de novo protein design and understanding, most notably the ESM-3 family of protein language models. Their core innovation lies in leveraging large-scale protein sequence data to enable the creation of novel proteins with desired functions – demonstrated by the successful in silico design and synthesis of esmGFP, a fluorescent protein evolved beyond natural limitations. Targeting pharmaceutical companies, biotechnology firms, and academic research labs, EvolutionaryScale provides access to ESM-3 via API and open-source models (ESM-3-open) to accelerate drug discovery and protein engineering efforts, backed by $142M in seed funding.

Cradle

Amsterdam, Netherlands

Cradle develops a generative AI platform for de novo protein design, enabling researchers to create and optimize proteins with desired properties. Their technology utilizes machine learning models trained on proprietary and user-supplied experimental data to generate novel protein sequences and predict their characteristics, accelerating the drug discovery and protein engineering processes. Cradle targets biotechnology and pharmaceutical companies, and their platform aims to reduce the time and cost associated with traditional protein development pipelines by minimizing the need for iterative lab experiments.